منابع مشابه
Bacterial plasminogen activators and receptors.
Invasive bacterial pathogens intervene at various stages and by various mechanisms with the mammalian plasminogen/plasmin system. A vast number of pathogens express plasmin(ogen) receptors that immobilize plasmin(ogen) on the bacterial surface, an event that enhances activation of plasminogen by mammalian plasminogen activators. Bacteria also influence secretion of plasminogen activators and th...
متن کاملGenetic analysis of Streptococcus uberis plasminogen activators.
BACKGROUND & OBJECTIVES Streptococci produce a diverse range of secreted plasminogen activators capable of converting mammalian plasminogen to plasmin in a species-specific manner. In all examples to date, the host animal's plasminogen and that of a number of additional species have been shown to interact with these molecules leading to the conclusion that the pathogenesis of streptococci is in...
متن کاملPlasminogen activators and plasminogen activator inhibitors in endometriosis.
Endometriosis is one of the most frequent benign gynecological diseases that affect women. Little is known about the pathogenesis and etiology of endometriosis, despite the numerous studies performed in this field. Although endometriosis is a benign disease, the endometrial tissue, after attachment to the peritoneum, has the ability to grow and invade the surrounding tissues. Similar to neoplas...
متن کاملPlasminogen activators. The old and the new.
T hrombosis of a coronary or cerebral artery is the most common cause of mortality and morbidity in the developed nations.' The proximate cause is most often atherosclerosis, and the most appropriate intervention is its prevention. Much progress has been made in identifying the risk factors predisposing to atherosclerosis, and, perhaps because of their recognition, a significant decrease in the...
متن کاملEditorial Comment Can Plasminogen Activators Be Improved?
T he widespread application of plasminogen activators in the treatment of myocardial infarction has resulted in a significant reduction in mortality.",2 Most patients have been treated with two very different drugs: streptokinase, a bacterial protein that is the product of fermentation technology dating from the 1930s, and recombinant tissue-type plasminogen activator (rt-PA), a human protein t...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2015
ISSN: 1538-7933
DOI: 10.1111/jth.12939